| Safecracker |
| Samba de Amigo (3) |
| Samurai Warriors 3 |
| Samurai Warriors Katana |
| Scarface: The World is Yours |
| Sega Superstars Tennis (4) |
| Sengoku Basara: Samurai Heroes |
| Sengoku Musou Katana |
| Shrek Forever After |
| Shrek The Third (2) |
| Shrek's Carnival Craze Party Games |
| Simpsons Game, The |
| Sin & Punishment (Virtual Console) |
| Sin & Punishment: Star Successor |
| Skate It |
| Sky Crawlers: Innocent Aces, The |
| Skylanders: Trap Team |
| Smarty Pants |
| SNK Arcade Classics Vol.1 |
| Sonic & Sega All-Stars Racing |
| Sonic and the Black Knight |
| Sonic and the Secret Rings (3) |
| Sonic Colors (4) |
| Sonic Riders: Zero Gravity (3) |
| Spectrobes: Origins (3) |
| Spider-Man 3 |
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